Could be several things. Flies too big, tippet too thick and / or floating. Could also have tried a different shape fly. They may have been drawn to your fly but turning away at last second as not looking like the natural they were feeding on (assuming there was a hatch?).
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You will be able to fish your flies through the layers by counting down in 5 second intervals before you start you retrieve. The point fly will eventually sink if the line is allowed to do k deep enough.
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