End of April might be early, fly usually appears mid-May but with the warm spring you might be OK this year. Nearly everybody ties on a Grey Wulff but your standard mayfly dry patterns will work as well. Locals tend not to use wets but I've got 'em on Lough Erne/Melvin Straddlebugs in the past.
Luska Bay generally gets the first hatches, Dromineer Bay used to be good too but has tailed off lately for some reason. If you get a chance to fish the spent gnat, then Youghal Bay is the place. I'd keep away from Killaloe and O'Brien's Bridge as it can be dangerous for a boat if you don't know the area.
Lots of boat hire places around the lough, it really depends on where you're based but you'll get info on that in any of the local pubs. :thumbs: